Hyaluronic acid (HA) is a non-sulphated glycosaminoglycan (GAG) and is composed of repeating polymeric disaccharides of D-glucuronic acid and N-acetyl-D-glucosamine linked by a glucuronidic β (1→3) bond. It is endowed with unique physiological and biological properties including high water-holding capacity, viscoelasticity and biocompatibility. HA is one of the most hydrophilic (water-loving) molecules in nature and can be described as nature’s moisturizer. It is synthesized by specific enzymes called HA synthases (HAS).

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