|
Catalog #
|
Compound
|
CAS ID
|
Structure
|
Notes
|
Eastinno Pricing
|
|
EI-SM-001
|
IWR-1-endo
|
1127442-82-3
|
 |
a Wnt/β-catenin inhibitor with an IC50 value of 180 nM.
|
specification：5mg 10mg
price: $60 $90
|
|
EI-SM-002
|
CHIR99021
|
252917-06-9
|
 |
a potent, ATP-competitive & highly selective GSK-3 inhibitor, which inhibits GSK-3α and GSK-3β with IC50 of 10 nM and 6.7 nM, respectively
|
specification：2mg 5mg 25mg
price: $70 $140 $460
|
|
EI-SM-003
|
LDN193189
|
1062368-24-4
|
 |
a selective BMP signaling inhibitor,with IC50 of 5 nM and 30 nM for inhibition of the BMP type I receptors ALK2 and ALK3, respectively
|
specification：2mg 5mg
price: $90 $130
|
|
EI-SM-004
|
SB431542
|
301836-41-9
|
 |
a potent and selective inhibitor of ALK5 with IC50 of 94 nM
|
specification：10mg 50mg
price: $110 $380
|
|
EI-SM-005
|
Y27632 2hcl
|
129830-38-2
|
 |
a selective Rho-kinase inhibitor
|
specification：2mg 5mg 10mg
price: $60 $100 $140
|
|
EI-SM-006
|
SAG
|
912545-86-9
|
 |
A potent agonist of Hedgehog (Hh)/Smoothened(Smo) signalling with EC50 of 3nM
|
specification：2mg 5mg
price: $90 $200
|
|
EI-SM-007
|
LY2157299
|
700874-72-2
|
 |
a potent TGFβ receptor I (TβRI) inhibitor with IC50 of 56 nM
|
specification：5mg 10mg
price: $140 $220
|
|
EI-SM-008
|
Vismodegib(GDC0449)
|
879085-55-9
|
 |
a potent and specific inhibitor of Hedgehog (Hh)/Smoothened(Smo) signaling with IC50 of 3nM
|
specification：5mg 10mg
price: $70 $170
|
|
EI-SM-010
|
（+）-JQ-1
|
1268524-70-4
|
 |
a BET bromodomain inhibitor, with IC50 of 77 nM/33 nM for BRD4(1/2)
|
specification：10mg 25mg
price: $220 $460
|
|
EI-SM-011
|
GDC0941
|
957054-30-7
|
 |
a potent inhibitor of PI3Kα/δ with IC50 of 3 nM
|
specification：5mg 10mg 50mg
price: $100 $140 $330
|
|
EI-SM-012
|
LY411575
|
209984-57-6
|
 |
a potent γ-secretase inhibitor with IC50 of 0.082 nM, which inhibits Notch cleavage with IC50 of 0.39nM
|
specification：10mg 50mg
price: $150 $480
|
|
EI-SM-013
|
NUTLIN 3
|
890090-75-2
|
 |
a potent and selective Mdm2 (a ubiquitin protein ligase for p53) antagonist with IC50 of 90 nM
|
specification：5mg 10mg 25mg
price: $90 $140 $300
|
|
EI-SM-014
|
PD0325901
|
391210-10-9
|
 |
a selective and non ATP-competitive MEK inhibitor with IC50 of 0.33 nM
|
specification：5mg 25mg
price: $60 $220
|
|
EI-SM-015
|
PD173074
|
219580-11-7
|
 |
a potent FGFR1 inhibitor with IC50 of ~25 nM, which also inhibits VEGFR2 with IC50 of 100-200 nM
|
specification：5mg 10mg
price: $60 $100
|
|
EI-SM-016
|
RG108
|
48208-26-0
|
 |
DNA methyltransferase Inhibitor with IC50 of 115 nM
|
specification：10mg 50mg
price: $90 $380
|
|
EI-SM-017
|
LY294002
|
154447-36-6
|
 |
an inhibitor of PI3Kα/δ/β with IC50 of 0.5 μM/0.57 μM/0.97 μM respectively
|
specification：10mg 25mg
price: $120 $220
|
|
EI-SM-018
|
Gefitinib
|
184475-35-2
|
 |
an EGFR inhibitor for Tyr1173, Tyr992, Tyr1173 and Tyr992 with IC50 of 37 nM, 37nM, 26 nM and 57 nM, respectively
|
specification：100mg 250mg
price: $40 $80
|
|
EI-SM-019
|
Rapamycin（sirolimus ）
|
53123-88-9
|
 |
a specific mTOR inhibitor with IC50 of ~0.1 nM
|
specification：5mg 25mg
price: $60 $220
|
|
EI-SM-020
|
ZSTK-474
|
475110-96-4
|
 |
an inhibitor of class I PI3K isoforms, mostly PI3Kδ, with IC50 of 37 nM
|
specification：10mg 50mg
price: $60 $220
|
|
EI-SM-021
|
Everolimus (RAD001)
|
159351-69-6
|
 |
an mTOR inhibitor of FKBP12 with IC50 of 1.6-2.4 nM.
|
specification：10mg 25mg
price: $90 $170
|
|
EI-SM-022
|
Tacrolimus (FK506）
|
104987-11-3
|
 |
binds to the immunophilin FKBP12; inhibits PP2B (calcineurin); reduces peptidyl-prolyl isomerase activity in T cells.
|
specification：50mg 100mg
price: $70 $140
|
|
EI-SM-023
|
BIO
|
667463-62-9
|
 |
a specific inhibitor of GSK-3α/β with IC50 of 5 nM, which activates Wnt signaling pathway.
|
specification：10mg 50mg
price: $120 $460
|
|
EI-SM-025
|
Dorsomorphin 2HCl
|
1219168-18-9
|
 |
a potent and selective inhibitor of ATR kinase with IC50 of 5 nM
|
specification：10mg 50mg
price: $120 $380
|
|
EI-SM-026
|
Sorafenib Tosylate
|
284461-73-0
|
 |
a multikinase inhibitor of Raf-1, B-Raf and VEGFR-2 with IC50 of 6 nM, 22 nM and 90 nM, respectively
|
specification：5mg 10mg 50mg
price: $120 $180 $540
|
|
EI-SM-027
|
Sunitinib Malate
|
341031-54-7
|
 |
a multi-targeted RTK inhibitor targeting VEGFR2 (Flk-1) and PDGFRβ with IC50 of 80 nM and 2 nM, which also inhibits c-Kit.
|
specification：50mg 100mg
price: $80 $120
|
|
EI-SM-028
|
Erlotinib HCl (OSI-744)
|
183321-74-6
|
 |
an EGFR inhibitor with IC50 of 2 nM.
|
specification：100mg 500mg
price: $120 $300
|
|
EI-SM-029
|
Lapatinib
|
231277-92-2
|
 |
a potent EGFR and ErbB2 inhibitor with IC50 of 10.8 and 9.2 nM, respectively.
|
specification：25mg 100mg
price: $90 $220
|
|
EI-SM-030
|
Afatinib (BIBW2992)
|
439081-18-2
|
 |
irreversibly inhibits EGFR/HER2 including EGFR(wt), EGFR(L858R), EGFR(L858R/T790M) and HER2 with IC50 of 0.5 nM, 0.4 nM, 10 nM and 14 nM, respectively.
|
specification：5mg 10mg
price $80 $140
|
|
EI-SM-031
|
AC480 (BMS-599626)
|
714971-09-2
|
 |
a selective and potent inhibitor of HER1 and HER2 with IC50 of 20 nM and 30 nM respectively.
|
specification：5mg 25mg
price: $140 $460
|
|
EI-SM-032
|
Imatinib (STI571)
|
152459-95-5
|
 |
a multi-target inhibitor of v-Abl, c-Kit and PDGFR with IC50 of 0.6 μM, 0.1 μM and 0.1 μM, respectively
|
specification：250mg 500mg
price: $60 $100
|
|
EI-SM-033
|
Nintedanib (BIBF 1120)
|
928326-83-4
|
 |
a potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β with IC50 of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/65 nM respectively.
|
specification：5mg 10mg 50mg
price: $100 $170 $540
|
|
EI-SM-034
|
Crizotinib (PF2341066）
|
877399-52-5
|
 |
a potent inhibitor of c-Met and ALK with IC50 of 11 nM and 24 nM, respectively.
|
specification：5mg 10mg 50mg
price: $90 $140 $460
|
|
EI-SM-036
|
Cabozantinib (XL184, BMS-907351)
|
849217-68-1
|
 |
a potent VEGFR2 inhibitor with IC50 of 0.035 nM and also inhibits c-Met, Ret, Kit, Flt-1/3/4, Tie2, and AXL with IC50 of 1.3 nM, 4 nM, 4.6 nM, 12 nM/11.3 nM/6 nM, 14.3 nM and 7 nM, respectively.
|
specification：5mg 10mg 50mg
price: $90 $140 $380
|
|
EI-SM-037
|
SSR128129E
|
848318-25-2
|
 |
an allosteric and selective FGFR1 inhibitor with IC50 of 1.9 μM.
|
specification：5mg 20mg
price: $80 $220
|
|
EI-SM-038
|
Dasatinib
|
302962-49-8
|
 |
a novel, potent and multi-targeted inhibitor of Abl, Src and c-Kit, with IC50 of <1 nM, 0.8 nM and 79 nM, respectively.
|
specification：25mg
price: $30
|
|
EI-SM-039
|
Alectinib (CH5424802)
|
1256580-46-7
|
 |
a potent ALK inhibitor with IC50 of 1.9 nM, sensitive to L1196M mutation.
|
specification：5mg 10mg 50m
price: $140 $220 $620
|
|
EI-SM-040
|
Ceritinib (LDK378)
|
1032900-25-6
|
 |
a potent inhibitor against ALK with IC50 of 0.2 nM.
|
specification：5mg 50mg
price: $120 $380
|
|
EI-SM-041
|
Venetoclax (ABT-199, GDC-0199)
|
1257044-40-8
|
 |
a Bcl-2-selective inhibitor with Ki of <0.01 nM.
|
specification：5mg 50mg
price: $220 $780
|
|
EI-SM-042
|
ABT-263 (Navitoclax)
|
923564-51-6
|
 |
a potent inhibitor of Bcl-xL, Bcl-2 and Bcl-w with Ki of ≤ 0.5 nM, ≤1 nM, and ≤1 nM, respectively.
|
specification：5mg 10mg 25mg
price: $100 $160 $300
|
|
EI-SM-043
|
RITA (NSC 652287)
|
213261-59-7
|
 |
induces DNA-protein and DNA-DNA cross-links with no detectable DNA single-strand breaks, and also inhibits MDM2-p53 interaction by targeting p53.
|
specification：5mg 10mg
price: $140 $220
|
|
EI-SM-044
|
Lenalidomide (CC-5013)
|
191732-72-6
|
 |
a TNF-α secretion inhibitor with IC50 of 13 nM.
|
specification：10mg
price: $30
|
|
EI-SM-045
|
Thalidomide
|
50-35-1
|
 |
Thalidomide inhibits an E3 ubiquitin ligase in CRBN-DDB1-Cul4A complex. It inhibits TNF α biosynthesis and bFGF-induced angiogenesis. It also induces apoptosis in human monocyte cultures, and suggested to inhibit HIV-1 replication.
|
specification：200mg
price: $60
|
|
EI-SM-046
|
YM155
|
781661-94-7
|
 |
a potent survivin suppressant by inhibiting Survivin promoter activity with IC50 of 0.54 nM, also slightly inhibits the interaction of Survivin with XIAP.
|
specification：5mg 10mg 25mg
price: $60 $100 $220
|
|
EI-SM-047
|
Regorafenib（BAY73-4506）
|
755037-03-7
|
 |
a multi-target inhibitor for VEGFR1, VEGFR2, VEGFR3, PDGFRβ, Kit, RET and Raf-1 with IC50 of 13 nM/4.2 nM/46 nM, 22 nM, 7 nM, 1.5 nM and 2.5 nM, respectively.
|
specification：25mg
price: $190
|
|
EI-SM-049
|
Tofacitinib citrate(CP690550)
|
540737-29-9
|
 |
a potent and selective inhibitor of JAK3 with IC50 of 1 nM.
|
specification：5mg 25mg
price: $50 $160
|
|
EI-SM-050
|
Fludarabine
|
21679-14-1
|
 |
a STAT1 activation inhibitor and a DNA synthesis inhibitor.
|
specification：5mg 10mg 25mg
price: $40 $80 $150
|
|
EI-SM-051
|
MK2206
|
1032350-13-2
|
 |
a highly selective inhibitor of Akt1/2/3 with IC50 of 8 nM/12 nM/65 nM.
|
specification：5mg 10mg 25mg
price: $90 $140 ￥$300
|
|
EI-SM-052
|
Nilotinib (AMN-107)
|
641571-10-0
|
 |
a Bcr-Abl inhibitor with IC50<30 nM.
|
specification：25mg 100mg
price: $60 $170
|
|
EI-SM-053
|
Paclitaxel
|
33069-62-4
|
 |
a chemo drug and a microtubule polymer stabilizer with IC50 of 0.1 pM
|
specification：10mg 50mg
price: $60 $220
|
|
EI-SM-054
|
Bortezomib (PS-341)
|
179324-69-7
|
 |
a potent 20S proteasome inhibitor with Ki of 0.6 nM.
|
specification：5mg 25mg
price: $60 $220
|
|
EI-SM-055
|
MG132
|
133407-82-6
|
 |
an inhibitor of proteasome with IC50 of 100 nM in a cell-free assay, and also inhibits calpain with IC50 of 1.2 μM.
|
specification：5mg 25mg 100mg
price: $40 $140 $380
|
|
EI-SM-056
|
Carfilzomib(PR171)
|
868540-17-4
|
 |
an irreversible proteasome inhibitor with IC50 of <5 nM.
|
specification：5mg 10mg 50mg
price: $140 $220 $540
|
|
EI-SM-057
|
DAPT (GSI-IX)
|
208255-80-5
|
 |
an inhibitor of γ-secretase and Notch, a γ-secretase substrate
|
specification：5mg 10mg 25mg
price: $60 $100 $170
|
|
EI-SM-058
|
Vorinostat (suberoylanilide hydroxamic acid, SAHA)
|
149647-78-9
|
 |
an HDAC inhibitor with IC50 of ~10 nM.
|
specification：200mg 500mg
price: $120 $180
|
|
EI-SM-059
|
Panobinostat (LBH589)
|
404950-80-7
|
 |
a broad-spectrum HDAC inhibitor with IC50 of 5 nM.
|
specification：10mg 50mg
price: $70 $220
|
|
EI-SM-060
|
Olaparib (AZD2281, KU0059436)
|
763113-22-0
|
 |
a selective inhibitor of PARP1/2 with IC50 of 5 nM/1 nM.
|
specification：10mg 25mg 100mg
price: $60 $120 $300
|
|
EI-SM-061
|
ML324
|
1222800-79-4
|
 |
a selective inhibitor of jumonji histone demethylase (JMJD2) with IC50 of 920 nM.
|
specification：10mg 50mg
price: $80 $250
|
|
EI-SM-063
|
Decitabine
|
2353-33-5
|
 |
a potent inhibitor of DNA methylation.
|
specification：10mg 25mg 50mg
price: $70 $140 $260
|
|
EI-SM-064
|
Azacitidine
|
320-67-2
|
 |
specifically inhibits DNA methylation by trapping DNA methyltransferases.
|
specification：50mg
price: $80
|
|
EI-SM-065
|
Trametinib (GSK1120212)
|
871700-17-3
|
 |
a highly specific and potent MEK1/2 inhibitor with IC50 of 0.92 nM/1.8 nM.
|
specification：5mg 10mg
price: $80 $120
|
|
EI-SM-066
|
U0126-EtOH
|
1173097-76-1
|
 |
a highly selective inhibitor of MEK1/2 with IC50 of 0.07 μM/0.06 μM.
|
specification：25mg 100mg
price: $120 $380
|
|
EI-SM-067
|
PD98059
|
167869-21-8
|
 |
a non-ATP competitive MEK inhibitor with IC50 of 2 μM.
|
specification：5mg 10mg
price: $70 $120
|
|
EI-SM-068
|
Vemurafenib (PLX4032, RG7204)
|
918504-65-1
|
 |
a novel and potent inhibitor of B-RafV600E with IC50 of 31 nM.
|
specification：10mg 50mg
price: $60 $220
|
|
EI-SM-069
|
Dabrafenib（GSK2118436)
|
1195765-45-7
|
 |
a mutant BRAFV600 specific inhibitor with IC50 of 0.8 nM, with 4- and 6-fold less potency against B-Raf(wt) and c-Raf, respectively.
|
specification：5mg 10mg 20mg
price: $70 $100 $140
|
|
EI-SM-070
|
SB203580
|
152121-47-6
|
 |
a p38 MAPK inhibitor with IC50 of 0.3-0.5 μM, 10-fold less sensitive to SAPK3(106T) and SAPK4(106T) and it blocks PKB phosphorylation with IC50 of 3-5 μM.
|
specification：25mg 50mg 100mg
price: $120 $220 $300
|
|
EI-SM-071
|
SP600125
|
129-56-6
|
 |
a broad-spectrum JNK inhibitor for JNK1, JNK2 and JNK3 with IC50 of 40 nM, 40 nM and 90 nM, respectively.
|
specification：10mg 50mg
price: $51 $200
|
|
EI-SM-072
|
Palbociclib (PD-0332991) HCl
|
827022-32-2
|
 |
a highly selective inhibitor of CDK4/6 with IC50 of 11 nM/16 nM, respectively.
|
specification：5mg 10mg
price: $90 $140
|
|
EI-SM-073
|
Pemetrexed
|
150399-23-8
|
 |
an antifolate and antimetabolite for TS, DHFR and GARFT with Ki of 1.3 nM, 7.2 nM and 65 nM, respectively.
|
specification：10mg 50mg
price: $100 $380
|
|
EI-SM-074
|
Doxorubicin (Adriamycin)
|
25316-40-9
|
 |
an antibiotic agent and a DNA intercalator that inhibits DNA topoisomerase II and induces DNA damage and apoptosis in tumor cells
|
specification：10mg 25mg
price: $70 $170
|
|
EI-SM-076
|
A66
|
1166227-08-2
|
 |
a potent and specific p110α inhibitor with IC50 of 32 nM.
|
specification：5mg 10mg 50mg
price: $140 $260 $780
|
|
EI-SM-077
|
BEZ235(NVP-BEZ235)
|
915019-65-7
|
 |
a dual ATP-competitive PI3K and mTOR inhibitor for p110α/γ/δ/β and mTOR(p70S6K) with IC50 of 4 nM /5 nM /7 nM /75 nM /6 nM, respectively. Inhibits ATR with IC50 of 21 nM.
|
specification：50mg 100mg
price: $90 $140
|
|
EI-SM-078
|
BKM120 (NVP-BKM120, Buparlisib)
|
944396-07-0
|
 |
a selective PI3K inhibitor of p110α/β/δ/γ with IC50 of 52 nM/166 nM/116 nM/262 nM, respectively.
|
specification：5mg 10mg
price: $140 $240
|
|
EI-SM-079
|
CAL-101 (Idelalisib, GS-1101)
|
870281-82-6
|
 |
a selective p110δ inhibitor with IC50 of 2.5 nM.
|
specification：10mg 50mg
price: $100 $380
|
|
EI-SM-080
|
Pazopanib
|
444731-52-6
|
 |
a multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFR, FGFR, c-Kit and c-Fms with IC50 of 10 nM, 30 nM, 47 nM, 84 nM, 74 nM, 140 nM and 146 nM, respectively.
|
specification：25mg 100mg
price: $60 $170
|
|
EI-SM-081
|
XAV-939
|
284028-89-3
|
 |
a selective inhibitor of Wnt/β-catenin signaling through tankyrase1/2 inhibition with IC50 of 11 nM/4 nM.
|
specification：10mg 25mg 50mg
price: $60 $140 $200
|
|
EI-SM-082
|
Alisertib (MLN8237)
|
1028486-01-2
|
 |
a selective Aurora A inhibitor with IC50 of 1.2 nM.
|
specification：5mg 10mg 50mg
price: $100 $170 $540
|
|
EI-SM-083
|
PD-1/PD-L1 inhibitor 1
|
1675201-83-8
|
 |
disrupts PD-1/PDL-1 interaction.
|
specification：5mg 25mg
price: $120 $400
|
|
EI-SM-086
|
Mitomycin C
|
50-07-7
|
 |
an antineoplastic antibiotic by inhibiting DNA synthesis.
|
specification：10mg 50mg 200mg
price: $80 $240 $480
|
中文
