IDT has the expertise to deliver custom-synthesized RNA with the yield and purity that today's researcher demands. RNA is shipped deprotected and desalted in 2–3 business days or deprotected and purified in 4–6 business days. Please inquire for turnaround on 5 µmole and 10 µmole RNA synthesis.

Available Lengths:RNA oligos are available from 10–90 bases for 100 nmole, 5–90 bases for 250 nmole and 1 µmole, and 5–50 bases for 5 µmole and 10 µmole.

2′-O-methyl RNA:2′-O-methyl RNA is a useful RNA analog that is resistant to degradation by single-stranded ribonucleases. To include a 2’ O-methyl modification in your RNA sequence, simply place a lowercase "m" in front of the base; for example, mAmGmCmU.

 

Large-Scale RNA Synthesis:RNA, RNA analogs and chimeras are available in quantities up to ten grams.  IDT continues the tradition of providing researchers with the highest quality RNA oligonucleotide synthesis, in quantities ranging from multi-mg to several grams.

 

Custom Services:

• Target validation and development programs for siRNA, DsiRNA, aptamers, ribozymes, antisense and others
• Extensive QC packages tailored to researchers' needs
• Sterile-filtered oligo preparations available, endotoxin free
• Harmonized protocols allow simple transfer to our kilo-scale cGMP manufacturing partner
• Contact Customer Service for more information

Technical Notes:

Generally for RNA oligos, 1 OD260 ≈ 100/x nanomoles, where x is the length of the oligos in bases. For the average 20mer RNA oligo, 1 OD = 5 nmoles.  Actual nanomoles per OD varies with sequence composition.

To learn more about what else makes RNA unique, click here.

About IDT

Integrated DNA Technologies (IDT) is a leader in manufacturing and developing products for the research and diagnostics life science market. IDT serves the areas of academic research, biotechnology, and pharmaceutical development. IDT was founded by Dr Joseph Walder in 1987. Since then, its development has been guided by an uncompromising approach to quality, a belief in the value of good service, and a determination to minimize consumer costs.

Serving over 80,000 life sciences researchers, IDT is widely recognized as the industry leader in custom oligonucleotides due to its capabilities in:

Analytical Sophistication—IDT pioneered the use of high throughput quality control (QC) methods and is the only oligonucleotide manufacturer to offer purity guarantees and 100% QC. Every oligonucleotide is analyzed by mass spectrometry and purified oligonucleotides receive further analysis by CE and HPLC.
Design Engineering—IDT maintains an engineering division dedicated to advancing synthesis, processing technology, and automation. An in-house machine shop provides rapid prototyping and custom part design/control.
Customer Support—IDT received over 100,000 calls last year with an average wait time of only 8 seconds.
Reagent and Input Control—IDT receives all solvents in large bulk containers, runs QC on all incoming materials, and performs bulk reagent formulation and functional QC on all reagents.
IDT has over 700 employees serving our worldwide customer base from headquarters in Coralville, Iowa, and facilities in San Diego, California; Leuven, Belgium; and Singapore.