Protein MEMO1 (Mediator Of Cell Motility 1, MEMO1) has alternative names: Hepatitis C virus NS5A-transactivated protein 7, Mediator Of ErbB2-Driven Cell Motility 1. MEMO1 protein may control cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton. Mediator of ERBB2 signaling. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization. Is required for breast carcinoma cell migration.
Bovine Protein MEMO1 (MEMO1) ELISA Kit employs a two-site sandwich ELISA to quantitate MEMO1 in samples. An antibody specific for MEMO1 has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and anyMEMO1 present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for MEMO1 is added to the wells. After washing, Streptavidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of MEMO1 bound in the initial step. The color development is stopped and the intensity of the color is measured.
Bovine Protein MEMO1 (MEMO1) ELISA Kit listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
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