Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for ACACA.
The Abbkine ACCα (phospho Ser80) Rabbit Polyclonal Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and detects endogenous levels of ACCα protein only when phosphorylated at S80. The antibody has been validaed in WB , IHC-P, ELISA and reacts with Human, Mouse, Rat samples.
Abbkine supplies below price/size: $100/30μl, $220/100μl, $360/200μl of Rabbit Anti-ACCα (phospho Ser80) Polyclonal Antibody at https://www.abbkine.com/product/accα-phospho-ser80-polyclonal-antibody-abp50468.
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