Protein tyrosine phosphatase, receptor type C encoded by PTPRC is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of PTPRC, which encode distinct isoforms, have been reported.
The Abbkine CD45 Mouse Monoclonal Antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen and detects endogenous CD45 proteins. The antibody has been validaed in WB, IF, IHC-P and reacts with Human samples.
Abbkine supplies below price/size: $100/30μl, $220/100μl, $360/200μl of Mouse Anti-CD45 Monoclonal Antibody at https://www.abbkine.com/product/cd45-monoclonal-antibody-abm40046.
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