Cytochrome c oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane. The complex consists of 13 mitochondrial- and nuclear-encoded subunits. The mitochondrially-encoded subunits perform the electron transfer and proton pumping activities. The functions of the nuclear-encoded subunits are unknown but they may play a role in the regulation and assembly of the complex. COX4I1 encodes the nuclear-encoded subunit IV isoform 1 of the human mitochondrial respiratory chain enzyme. It is located at the 3' of the NOC4 (neighbor of COX4) gene in a head-to-head orientation, and shares a promoter with it. Pseudogenes related to COX4I1 are located on chromosomes 13 and 14. Alternative splicing results in multiple transcript variants encoding different isoforms.
The Abbkine COX IV Mouse Monoclonal Antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen and detects endogenous COX IV protein. The antibody has been validaed in WB, IHC-P, IF and reacts with Human, Mouse, Rat samples.
Abbkine supplies below price/size: $100/30μl, $220/100μl, $360/200μl of Mouse Anti-COX IV Monoclonal Antibody at https://www.abbkine.com/product/cox-iv-monoclonal-antibody-abm40033.
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