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Custom siRNA Construction Services
Custom siRNA Construction Services
Place of Origin:
China
Brand:
Shanghai ShineGene Molecular Biotech,Inc
Model:
Cat.No.:SG00105
Supplier:
Shanghai ShineGene Molecular Biotech,Inc.
Price:
Hits:
1795 
Updated:
3/21/2020
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  • Product Detail
  • Company Profile
    Gene silencing of target mRNA by RNA interference (RNAi) has dramatically enhanced the arsenal of genetic tools that can be used to study gene function. RNAi is a process used by plants and invertebrates to specifically inactivate gene function. It has been shown that double-stranded RNA (dsRNA) complementary to particular messenger RNA (mRNA) can specifically inactivate gene function through the RNAi pathway in mammalian systems as well. Small interfering RNAs (siRNAs) are generated in vivo from long precursor molecules through the action of a specific RNAase III endonuclease called Dicer. Dicer initiates the cleavage of the precursor into ~22 nucleotide (nt) double-stranded duplexes with two nt 3'-overhangs and 5' phosphate termini termed short interfering RNAs (siRNAs). The siRNA is subsequently incorporated into the RNA induced silencing complex (RISC), a protein/RNA complex. The siRNA allows specific recognition of the mRNA target and the endonuclease function of the RISC results in cleavage of mRNA and thus loss of gene expression.

    Price/Construct : €200 (Additional fees for vectors)

    We will design, construct, and package siRNA-expressing vector constructs targeting your gene of interest. You only provide the GenBank (or other public database) accession number to a gene sequence and choose one of our siRNA cloning and expression vectors. We can provide the following service:

    1.Select siRNA sequences based on parameters that, in our experience, are most likely to select effective siRNA.

    2.Synthesize and clone template sequences for the siRNA into a vector of your choice to produce siRNA-expressing vector constructs.

    3.Sequence the constructs to confirm correct cloning.

    4.Package and titer each construct. Deliver the plasmid and packaged constructs to you.
    E-mail:master@shinegene.org.cn or shinegene@vip.163.com
    bio-equip.cn
    ShineGene Bio-Technologies, Inc., located in Shanghai, P.R. China, is a bio-company specialized in providing bio- technical services including Gene Synthesis,Peptide Synthesis,Real Time PCR, Fluorogenic Probe Design,Fluorogenic Probe Label,HRP Enzyme Stabilizer,X-gal,IPTG,ProClin300etc. and supplying reagents such as Hotstart Taq polymerase, dNTPs, qPCR mastermix,one step qPCR kits,First Strand cDNA Synthesis Kits,etc. ShineGene also undertake some OEM or OED orders as well as production task.ShineGene works at the cutting edge of development in PCR, quantitative real-time PCR, transposon and RNA technologies. ShineGenes mission is to provide new tools of excellent quality and extreme purity to the scientific community. Therefore research and development is a continuous process in our company.

    http://www.synthesisgene.com
    http://www.shinegene.org.cn/englsih
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