The protein encoded by RB1 is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in RB1 are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. RB1 (RB Transcriptional Corepressor 1) is a Protein Coding gene. Diseases associated with RB1 include Retinoblastoma and Small Cell Cancer Of The Lung, Somatic. Among its related pathways are Arrhythmogenic right ventricular cardiomyopathy (ARVC) and DNA Damage.
Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: wb dilution 1:1000.
Rb (Acetyl-K873/K874) Polyclonal Antibody product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Find more details at https://www.abbkine.com/product/rb-(acetyl-k873/k874)-polyclonal-antibody-abp60102/
bio-equip.cn
中文
