The compact MIRO CANVAS provides true walk-away automation of complex next generation sequencing (NGS) library preparation and hybridization protocols, requiring only 15 minutes of hands-on time. The affordable and easy-to-use system uses innovative MIRO cartridges to minimize reagent consumption and produce high quality results with verified protocols for long-read sequencing, target enrichment and on-demand processing of samples.

Fully automated
Simple, walk-away automation for on-demand NGS sample preparation

Efficient
Minimize costs with up to 75 % reduction in reagent use and only 15 minutes of hands-on time

Flexible
Established NGS sample prep protocols for both short- and long-read sequencing platforms
 

Droplets are controlled using digital microfluidics technology
 
 

MIRO CANVAS uses digital microfluidics to perform sample preparation steps within the singe-use MIRO cartridge. Sample and reagents are pipetted into the cartridge, and the microfluidics system automatically performs steps required for sample and library preparation, without user intervention, to produce samples for sequencing. 
 
MIRO technology
MIRO technology uses electromechanical forces to move droplets over an array of electrodes. The electrode board has four thermal and four magnetic zones so that thermal cycling and magnetic bead operations can be performed automatically. Droplets move within the cartridge and are surrounded by air. The microfluidics technology also enables reduction of volumes for reduced running costs.

 
MIRO cartridge
The system uses MIRO cartridges, which are compatible with all commonly used reagents for sample preparation and enable easy experimental set-up. It is electronics-free, and incorporates microfluidic channels that sit in a layer above an open electrowetting plane, where the movement of droplets is controlled digitally by the electrodes that the cartridge sits upon.

 
Full walk-away automation
The system integrates steps necessary to perform sample preparation, including thermal cycling and magnetic bead operations, to minimize hands-on time and provide complete walkaway automation. The system senses reactions during the run, and ensures that all reagents and processes follow the same protocol from day to day, or site to site.

  
Simple run set-up
The onboard touchscreen on the MIRO CANVAS guides the user through setting up the run in minutes. The system also senses when a reagent has been loaded, and prompts the user to move onto the next step.

 
Long DNA Fragments
The microfluidics technology used in MIRO CANVAS provides a gentle environment and is favorable to long DNA fragments.

 
See it work