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Merck Develops Alternative CRISPR Genome Editing Method

hits:670     Date:05/18/17
New technology to improve genome editing, advance new possibilities for research
Creates method to rapidly deploy newly discovered bacterial CRISPR systems in disease-specific applications
Research published in prestigious journal, Nature Communications
Darmstadt, Germany, May 17, 2017 鈥 Merck, a leading science and technology company, has developed a new genome editing tool that makes CRISPR more efficient, flexible and specific, giving researchers more experimental options and faster results that can accelerate drug development and access to new therapies.
This new technique, called 鈥減roxy-CRISPR,鈥 provides access to previously unreachable areas of the genome. Most natural CRISPR systems, found in bacteria, cannot work in human cells without significant re-engineering. However, proxy-CRISPR provides a rapid and simple method to increase their usability without the laborious need to re-engineer native CRISPR proteins.

The company has filed several patent applications on the proxy-CRISPR technology. These patent applications directed to the proxy-CRISPR technology are just some of several CRISPR patent application filings made by the company since 2012.
鈥淲ith more flexible and easy-to-use genome editing technologies, there is greater potential in research, bioprocessing and novel treatment modalities,鈥 said Udit Batra, Member of the Merck Executive Board and CEO, Life Science. 鈥淎s a leader in genome editing, Merck鈥檚 new technology is just one example of our commitment to solving challenges in the genome editing field, and we will continue to make CRISPR research a priority.鈥
Merck鈥檚 research on proxy-CRISPR, 鈥淭argeted Activation of Diverse CRISPR-Cas Systems for Mammalian Genome Editing via Proximal CRISPR Targeting,鈥 was published in the April 7, 2017 edition of Nature Communications. The article explains how to make CRISPR more efficient, flexible and specific by opening up the genome for the cutting of DNA, giving researchers more editing options.

CRISPR genome editing technology is advancing treatment options for some of the toughest medical conditions faced today, including chronic illnesses and cancers for which there are limited or no treatment options. The applications of CRISPR are far ranging鈥攆rom identifying genes associated with cancer to reversing mutations that cause blindness. CRISPR enables genome editing using an enzyme called Cas9 to cut DNA, but this has limited targeting abilities. This limitation led to Merck鈥檚 focus on proxy-CRISPR.
Merck has a 14-year history in the genome editing field, and was the first company to globally offer custom biomolecules for genome editing (TargeTronTM biomolecules and zinc finger nucleases), driving adoption of these techniques within the global research community. Merck was also the first to manufacture arrayed CRISPR libraries covering the entire human genome, accelerating cures for diseases by allowing researchers to explore more questions about the root causes. Merck supports development gene- and cell-based therapeutics and manufactures viral vectors, as well. In 2016, the company launched a genome editing initiative aimed at advancing research in this area through a dedicated team and enhanced resources, further solidifying the company鈥檚 commitment to this field.
The new technology is a follow-on to Merck鈥檚 existing CRISPR applications. The company鈥檚 next suite of genome editing tools for the research community, to be launched later in 2017, will include novel and modified versions of Cas and Cas-like proteins.
Merck鈥檚 CRISPR Epigenetic Activator (p300-Cas9), which advances the way scientists explore epigenetic modification and associated diseases, was recognized as one of the Top 10 Innovations by The Scientist in 2015.
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About Merck
Merck is a leading science and technology company in healthcare, life science and performance materials. Around 50,000 employees work to further develop technologies that improve and enhance life 鈥 from biopharmaceutical therapies to treat cancer or multiple sclerosis, cutting-edge systems for scientific research and production, to liquid crystals for smartphones and LCD televisions. In 2016, Merck generated sales of 鈧15 billion in 66 countries.
Founded in 1668, Merck is the world's oldest pharmaceutical and chemical company. The founding family remains the majority owner of the publicly listed corporate group. Merck holds the global rights to the 鈥淢erck鈥 name and brand. The only exceptions are the United States and Canada, where the company operates as EMD Serono, MilliporeSigma and EMD Performance Materials.
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